Gout induced by L-dopa and decarboxylase inhibitors.
نویسندگان
چکیده
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منابع مشابه
Advances in Neurology, Volume 2. Treatment of Parkinsonism—The Role of Dopa Decarboxylase Inhibitors
This is an excellent compendium of current information on the status of various Dopa decarboxylase inhibitors in clinical practice. The book contains excellent articles on the experimental pharmacology of these inhibitors as well. This information is of importance because inhibitors of Dopa decarboxylase promise to play an important role in the treatment of Parkinson's disease. L-Dopa, as is ge...
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Seven patients with Parkinsonism previously on l-dopa were placed on a regimen of l-dopa and alpha methyl dopa hydrazine (a dopa decarboxylase inhibitor). Two of these patients had previously shown marked clinical deterioration of the l-dopa improvement when given pyridoxine. None of the seven patients receiving alpha methyl dopa hydrazine demonstrated any change in their condition when given p...
متن کاملModification of the cardiovascular effects of L-dopa in anesthetized dogs by inhibitors of enzymes involved in catecholamine metabolism.
The influence of various enzyme inhibitors on the cardiovascular effects of L-dopa (methylester) has been studied to determine the sites of action of the drug or a responsible metabolite. L-Dopa, 10 mg/kg, iv, had minor early effects on heart rate and blood pressure in normal dogs, but in animals with inhibition of monoamine oxidase (MAO), it caused tachycardia and severe hypotension of gradual...
متن کاملModification of the cardiovascular effects of L-dopa by decarboxylase inhibitors.
Intravenously infused L-dopa (0.3 mg/kg per min) produced hypertension and cardiac arrhythmias in halothane anesthetized dogs. Biochemical studies showed that the heart, kidney, and brain of these animals accumulated significant amounts of catecholamines formed from the administered precursor. Pretreatment of dogs with an extracerebral inhibitor of dopa decarboxylase [D,L-alpha-hydrazino-alpha-...
متن کاملMicrodialysis with radiometric monitoring of L-[β-11C]DOPA to assess dopaminergic metabolism: effect of inhibitors of L-amino acid decarboxylase, monoamine oxidase, and catechol-O-methyltransferase on rat striatal dialysate.
The catecholamine, dopamine (DA), is synthesized from 3,4-dihydroxy-L-phenylalanine (L-DOPA) by aromatic L-amino acid decarboxylase (AADC). Dopamine metabolism is regulated by monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT). To measure dopaminergic metabolism, we used microdialysis with radiometric detection to monitor L-[β-(11)C]DOPA metabolites in the extracellular space of th...
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ورودعنوان ژورنال:
- Postgraduate medical journal
دوره 52 606 شماره
صفحات -
تاریخ انتشار 1976